Granulocyte Colony Stimulating Factor(G-CSF)

GRANULOCYTE COLONY STIMULATING FACTOR

  • Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.
  • The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim.
  • G-CSF is produced by endothelium, macrophages, and a number of other immune cells.

Actions of G-CSF:
White blood cells

  • The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates proliferation and differentiation into mature granulocytes. G-CSF timulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.

Hematopoietic system

  • G-CSF is also a potent inducer of hematopoietic stem cell mobilization from the bone marrow into the bloodstream.

Neurons

  • G-CSF can also act on neuronal cells as a neurotrophic factor.

Medical use:

  • Chemotherapy induced neutropenia.
  • Before blood donation
  • G-CSF is also used to increase the number of hematopoietic stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem cell transplantation.
  • Stem cell transplants
  • G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate for conditioning regimens.
  • Kostmann's syndrome (severe congenital neutropenia)

Exam Question

  • Drug of choice for Neutropenia due to cancer chemotherapy is Filgrastim.
  • G-CSF stimulates production of a wider variety of hematopoietic stem cells.
  • Filgrastim is used in treatment of Neutropenia.
  • Treatment in a child with recurrent severe bacterial infections and diagnosed of having Kostmann's syndrome is G-CSF.
Don't Forget to Solve all the previous Year Question asked on Granulocyte Colony Stimulating Factor(G-CSF)