Acrodermatitis enteropathica

ACRODERMATITIS ENTEROPATHICA
  • Etiology
  • Autosomal recessive
  • Inherited form of zinc deficiency
  • Result of a mutation in a zinc transport protein - decreased ability to absorb zinc from dietary sources
Other names:
  • Brandt syndrome
  • Danbolt–Closs syndrome
  • Congenital zinc deficiency
Clinical manifestations
Triad of

  • Acral dermatitis (face, hands, feet, anogenital area)
  • Alopecia
  • Diarrhea
Treatment
  • Requires lifelong zinc supplementation
  • 1-3 mg/kg of zinc gluconate or sulfate is administered orally each day
Other types:
  1. Acrodermatitis chronica atrophicans: skin atrophy in Lyme's disease
  2. Acrodermatitis continua/ Acrodermatitis pustulosa: form of pustular psoriasis
Exam Question
  • Autosomal recessive
  • Inherited form of zinc deficiency
  • Triad of

  1. Acral dermatitis (face, hands, feet, anogenital area)
  2. Alopecia
  3. Diarrhea

  • Treatment
  • Requires lifelong zinc supplementation
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