Fluoxetine

PROPERTIES:
  • Potent reuptake blocker of Serotonin 
  • Non sedating Antidepressant is Fluoxetine 
  • SSRIs (Selective Serotonin Reuptake Inhibitors)
  • Mode of action of fluoxetine Inhibition of axonal uptake of 5HT
PHARMACOKINETICS:
Bioavailability 60–80%
Protein binding 94–95%
Metabolism Liver (mostly CYP2D6-mediated)
Biological half-life 1–3 days (acute)4–6 days (chronic)
Excretion Urine (80%), faeces (15%)
USES:

  • Major depressive disorder
  • obsessive-compulsive disorder (OCD), 
  • Post-traumatic stress disorder (PTSD), 
  • Bulimia nervosa, 
  • Panic disorder, 
  • Premenstrual dysphoric disorder 
  • Trichotillomania.
  • Cataplexy, 
  • Obesity, 
  • Alcohol dependence,as well as binge eating disorder
  • . Autism spectrum disorders with moderate success in adults
OVERDOSE:
  • overdose, most frequent adverse effects include:
  • Nervous system effects
    anxiety
    nervous
    nessinsomnia
    drowsiness
    fatigue or asthenia
    tremor
    dizziness orightheadedness
    Gastrointestinal effects
    anorexia
    nausea
    diarrhea
    vaso
    dilationdry mouth
    abnormal vision
    Other effects
    abnormal ejaculation
    rash
    sweating
    decreased libido
ADVERSE EFFECTS:
  • Abnormal ejaculation,
  • Anorexia, 
  • Anxiety, 
  • Asthenia, 
  • Diarrhea, 
  • Dry mouth, 
  • Dyspepsia, 
  • Flu syndrome, 
  • Impotence, 
  • Insomnia, 
  • Decreased libido, 
  • Nausea, Nervousness, 
  • Pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilatation, and yawning.
  • Fluoxetine is considered the most stimulating of the SSRIs (that is, it is most prone to causing insomnia and agitation)
  • It also appears to be the most prone of the SSRIs for producing dermatologic reactions (e.g. urticaria (hives), rash, itchiness, etc.
Exam Question
  • Drug of choice for OCD is Fluoxetine
  • Fluoxetine is a potent reuptake blocker of Serotonin
  • Fluoxetine is palpitations, breathlessness, sweating and a fear of impending death. She has one episode of such attacks every week. There are no identifiable triggers for the episodes .Fluoxetine is the Drug of choice.
  • Loose stools is The common side effect with Fluoxetine therapy 
  • Non sedating Antidepressant is Fluoxetine 
  • Mode of action of fluoxetine Inhibition of axonal uptake of 5HT
  • Side effect of Fluoxetine is Weight gain, Anxiety,Sweating & Diarrhoea
  • Drug of choice in depression in old person is Fluoxetine

Don't Forget to Solve all the previous Year Question asked on Fluoxetine