Rhabdomyolysis

RHABDOMYOLYSIS
Causes:
  • Crush or Anoxic injuries, Cocaine use, Alcohol intoxication (particularly with prolonged immobility), Exposure hypothermia, Compromised kidney and liver function, Diabetes mellitus, Hypothyroidism
  • Drugs: Statins, protease inhibitors, erythromycin, itraconazole, clarithromycin, diltiazem
Clinical & Laboratory findings
  • Myalgias and weakness are usually present.
  • Urinary dipstick testing positive for blood (actually myoglobin) in the absence of RBCs
  • Serum creatine kinase level is elevated (markedly).
  • Elevated serum levels of AST, ALT and lactate dehydrogenase
Complications:
  • Myoglobinuria
  • Acute Renal Failure
Treatment:
  • Vigorous fluid resuscitation
Exam Question
RHABDOMYOLYSIS
Causes:
  • Crush or Anoxic injuries
  • Drugs: Statins
  • Clinical & Laboratory findings
  • Myalgias and weakness are usually present.
Complications:
  • Myoglobinuria
  • Acute Renal Failure

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