Granuloma Inguinale

  • Granuloma inguinale caused by Klebsiella granulomatis/Calymmatobacterium granulomatis
  • The lesion starts as a small painless papule which then ulcerates into a beefy red granulomatous ulcer with rolled edges that bleeds easily. 
  • Lesions are most commonly seen on prepuce, coronal sulcus, frenum, and glans in men and on labia minora and fourchette in women.
  • The diagnosis is confirmed by by the presence of Donovan bodies in tissue smears. These are gram-negative intracytoplasmic cysts filled with deeply staining bodies that may have a safety-pin appearance. 
  • Treatment:streptomycin, tetracyclines & cotrimoxazole.
Exam Question
  • Donovan bodies are seen in Granuloma inguinale.
  • Treatment of granuloma inguinale is tetracycline.
  • A 25 year old male presents to the clinic with a lesion on his penis. On examination he was noted to have a beefy red ulcer on the glans which bled when touched. Smear taken from the ulcer showed gram-negative intracytoplasmic cysts filled with deeply staining bodies that had a safety-pin appearance. What is he most likely suffering from Granuloma Inguinale. The hard chancre is seen in Granuloma Inguinale.
  • A 26 year male patient presented with a granulomatous penile ulcer. On Wright Giemsa staining, tiny organisms of 2 microns are seen engulfed by macrophages. Calymmatobacterium granulomatis is the causative organism
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