Pellagra

PELLAGRA
  • Pellagra is a disease that occurs due to deficiency of Niacin (Vitamin-B3).
  • It is characterized by classical triad of 3Ds :-
  1. Diarrhea
  2. Dermatitis
  3. Dementia
Exam Question
  • Pellagra is characterized by classical triad of 3Ds :-Diarrhea ,Dermatitis ,Dementia.
  • Pellagra is due to deficiency of Niacin.
  • In South India pellagra is reported in population eating Jowar.
  • Pellagra in jowar eating population is due to excess of Leucine.
  • Patient presenting with pellagra, parkinsonism, convulsions, anemia and kidney stones has deficiency of Pyridoxal Phosphate.
  • Development of pellagra like skin lesion in carcinoid syndrome is due to inadequate conversion of Tryptophan to Niacin.
  • A 10 year old child is suspected of having pellagra because of chronic symptoms including diarrhea, a red scaly rash, and mild cerebellar ataxia.
  • However, his diet is not deficient in protein and he appears to be ingesting adequate amounts of niacin. A sister has a similar problem. Chemical analysis of his urine demonstrates large amounts of free 
  • amino acids. Hartnup's Disease is the most probable diagnosis.
  • Consumption of maize may aggravate Pellagra. As some strains of maize contains excess of Leucine which interferes in the conversion of Tryptophan into Niacin. Casal's paint necklace is caused by Pellagra.
  • Photosensitive dermatitis are Psoriasis, Pellagra, Pemphigus, SLE, Congenital erythropoietic porphyria
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