Amniotic Fluid

  • Best method for the diagnosis of lung maturity is Phosphtidyl glycerol estimation in amniotic fluid
  • The presence of increased levels of Acetyl cholinesterase in amniotic fluid is an indicator of open neural tube defect in the fetus
  • Nile blue sulphatase test in amniotic fluid is for Skin maturity
  • Amniotic fluid contains acetyl cholinesterase enzyme can be a diagnosis of Open spina bifida
  • Amniotic fluid is maximum at 38 weeks of pregnancy
  • Amniotic fluid index (AFI) is calculated by adding the vertical depths of the largest pocket in each of four equal uterine quadrants
  • Fluid restriction may lower the AFI
  • Significant hydramnios is defined by an index greater than 24 cm
  • Sonographically, oligohydramnios is defined when the maximum vertical pool of liquor is less than 2 cm or when amniotic fluid index (AFI) is less than 5 cm 
  • Sonography of a term multigravida shows amniotic fluid index of 3 cm. The fetus may have renal agenesis
  • Prenatal diagnosis at 16 weeks of pregnancy can be performed using Amniotic fluid
  • The amount of amniotic fluid at 12 weeks of pregnancy is 50 ml
  • Amniotic fluid at 38 weeks in normal pregnancy is 800 cc
  • pH range of amniotic fluid is 7.0 - 7.5
  • pH of amniotic fluid at later weeks of gestation is 7.2
  • Golden colour amniotic fluid is seen in Rh incompatibility
  • The amniotic fluid is completely replaced in every 3 hours
  • The major contribution of the amniotic fluid after 20 weeks of gestation is Fetal urine
  • At 15 weeks of gestation, increased alpha feto計rotein in amniotic fluid is seen in Intrauterine death
  • Lecithin Sphingomyelin ratio in amniotic fluid is used to assess the maturity of Fetal lung
  • Multiparous woman with IUD ad衫itted for strong labour pains can go into shock with cyanosis, respiratory disturbance and pulmonar edema in case of Amniotic fluid embolism Risk of amniotic fluid embolism is greatest During labour
  • Amniotic fluid embolism causes Shock, DIC & bleeding tendency
  • Amniotic fluid is mainly produced by Fetus
  • Surfactant appears in amniotic fluid at the gesta‑tional age of 32 weeks
  • The amniotic fluid is in balance by Excretion by fetal kidneys, Maternal hemostasis & Fetal intestinal absorption
  • Excessive ac苞umulation of amniotic fluid shoewng polyhydramnios is likely to be associated with Twinning, Microencephaly & Oesophageal atresia
  • Antenatal screening is done using Cord blood, Amniotic fluid & Chorionic villi
  • Amniotic fluid volume estimation is not done for antenatal diagnosis of Down's syndrome 
  • DIC may be caused by Amniotic fluid embolism
  • Polyhydroaminosis is volume of amniotic fluid more than 2000 ml
  • Lendrum's stain is done for Amniotic fluid embolism.
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