Folic acid

  • Daily dose of folic acid for women of child bearing age is 0.4 mg
  • Maximum permissible radiation dose in pregnancy is 5.0 rad
  • Vitamin B12 and folic acid supplementation in megaloblastic anemia leads to the improvement of anemia due to Increased DNA synthesis in bone marrow 
  • Folic acid acts as a cofactor for metabolism of sulphur containing amino acids
  • Both active and passive transport of folic acid absorbtion mechanism occurs in proximal jejunum
  • Folic Acid is a Water Soluble Vitamin
  • Conversion of glycine to serine requires Folic acid
  • The gene responsible for folic acid transport is situated on 21chromosome
  • Iron and folic acid supplementation forms Specific protection
  • Both folic acid and vitamin B12 are required for DNA synthesis
  • Both folic acid and vitamin B12 causes megaloblastic anaemia
  • Preconceptionally folic acid is given for prevention of neural tube defects
  • Folic Acid is present in leafy vegetables, spinach, paneer
  • Requirement of folic acid per day in pregnancy is 500 mcg
  • Folic acid requirement during lactation is 150 microgram/day
  • Hyperplasia of bone marrow, Megakaryocytic RBC & Achlorhydria can be corrected by administering folic acid
  • Folic acid is given during First trimester of pregnancy 
  • Recommended daily dietary requirment of folate (folic acid) in children is 80-120 μg
  • Major form of folic acid to transfer one carbon is Methylene THF
  • Blood form of folic acid is Methylene THF
  • Phenytoin, Phenobarbitone & Primidone drugs interfere with folic acid metabolism
  • Folic acid supplementation is necessory for Pregnant females
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