MEASLES

  • Giant cells seen in Measles are called Warthin-Finkeldey cells
  • The function of the nucleocapsid proteins of measles virus is to Protect the genome RNA from nuclease digestion and recognise the location in the cell membrane for budding
  • Measles have High secondary attack rate
  • Measles is Not infectious in prodromal stage 
  • Measles Infection confers lifelong immunity
  • 9 months to 14 years age group is targeted in the catch up vaccination strategy of WHO for elimination of measles
  • 96% is the recommended minimum immunization coverage to ensure measles eradication
  • Complication of measles are Myocarditis, Appendicitis & SSPE
  • The rash in measles occurs first in occurs first in the Post auricular region
  • Secondary attack of measles is less than that of rubella
  • Most serious complication of measles is Meningoencephalitis 
  • In the UIP blindness can be prevented by the administration of Measles vaccines
  • Reconstituted measles vaccine should be used with in 1 hour
  • Measles vaccine if contaminated can cause Toxic Shock Syndrome (TSS)
  • Measles vaccine given to contact of measles case exerts protective effect within 7 days
  • India started 2-dose vaccination strategy for measles, in 2010
  • Secondary attack rate of measles is 30-40%
  • Incubation period of measles is 10-14 days
  • Vaccine of measles is live attenuated
  • Measles vaccination compagin between 9-14 years age for elimination is Catch up
  • Subacute sclerosing pan-encephalitis is associated with Measles
  • Bolognini's symptom (a feeling of crepitationoccuring from gradual increasing pressure on the abdomen) is seen in Measles
  • Post exposure vaccination for measles should be done in 3 day of exposure
  • After the appearance of rash, prophylactic isolation of measles case is necessary for a minimum of 5 days
  • Measles is infective for Four days before and five days after rash
  • Syncytium formation is a property of Measles virus
  • Measles vaccine is Contraindicated in neomycin allergic patients
  • Catch up: One time nation wide vaccination 9 month- 14 years old children, Keep up: Vaccinate > 95% successive birth & Follow up: Nationwide vaccination every 2-4 years are strategies for measles elimination
  • Measles elimination criteria is <1 br=""> Otitis media is the most common complication of measles 
  • Mortality rate in measles encephalitis is 20-30%
  • Mortality rate of measles in developing countries 10%
  • Human is the only reservoir for Measles
  • Most common cause of post-measles death RTI
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