OSTEOSARCOMA

  • Mutation of RB gene can be related to the development of osteosarcoma
  • Hyperglycemia is associated with Osteosarcoma
  • 'T - 10 Protocol' for treatment of osteosarcoma includes 
  1. High Dose Methotrexate
  2. Bleomycin, Cyclophosphamide, Doxorubicin (BCD)
  3. Etoposide
  • MRI, CT chest & Bone scan ARE required in Osteosarcoma
  • Osteosarcoma is a 'Pulsating tumor' of the bone
  • Parosteal osteosarcoma may involve medulla
  • Most common site of osteosarcoma is Lower end of femur
  • Histology of Myositis ossificans mimics Osteosarcoma
  • A patient with Osteomyelitis & Paget's disease of bone are predisposed to develop osteosarcoma
  • Codman's triangle is the characteristic x-ray finding of Osteosarcoma
  • Methotrexate is used in high doses in Osteosarcoma
  • Radiological feature of osteosarcoma is Sunray appearance
  • Osteosarcoma is least likely to regress spontaneously
  • Most common second malignancy in patients with familial retinoblastoma is Osteosarcoma
  • Osteosarcoma commonly affects Metaphysis
  • Osteosarcoma is differentiated from myositis ossificans by radiology by Peripheral field of differentiation
  • Osteosarcoma is not sensitive to radiotherapy
  • Calcification in osteosarcoma is due to presence of Osteoid matrix
  • A child is diagnosed with osteosarcoma based on sunray appearance on X-ray. This is because of Periosteal reaction
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