Pyridoxine (Vitamin B6)

  • Isoniazid,Cycloserine,Penicillamine, Levodopa & Hydralazine interfere with utilization and action of vitamin B6 (Pyridoxine)
  • Pyridoxine is required for Heme synthesis
  • The co-factor for glycogen phosphorylase in glycogenolysis is Pyridoxal phosphate
  • Large doses of pyridoxine are of value in some cases of Homocystinuria
  • Cystathionine lyase requires Pyridoxine as cofactor 
  • Pyridoxine should be given when treating with Isoniazid
  • PLP is the coenzyme form of Pyridoxine 
  • Transamination reaction requires Pyridoxine
  • Pyridoxine is associated with glycogen phosphorylase
  • Folinic acid and vitamin B6 medications essential for ameliorating the toxicity of pemetrexed
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