Thiamine Deficiency

  • Thiamine deficiency causes decreased energy production because It is co-enzyme for pyruvate dehydrogenase
  • α-Ketoglutarate dehydrogenase activities will decrease in thiamine deficiency
  • Thiamine deficiency lead to lactic acidosis
  • Beri-Beri is caused by Thiamine
  • Thiamine deficiency may be seen in Chronic alcoholism, Heart failure patients on diuretics & Starvation
  • Constellation of neuropathy, muscle weakness and wasting, cardiomegaly, edema, ophthalmoplegia, confabulation strongly suggest Thiamine deficiency
  • Vitamin deficiency seen in alcoholic with dementia is of Thiamine
  • Wernikes encephalopathy is due to deficiency of Thiamine
  • Korsakoff psychosis is caused by Thiamine deficiency
  • Earliest symptom showing improvement from classical triad of Wernicke's encephalopathy to thiamine therapy is Ophthalmoplegia
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